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Activity in a prepartum and postpartum period with patient suffering from miltiple sclerosis
Řeháková, Anna ; Pavlasová, Lenka (advisor) ; Ehler, Edvard (referee)
An activity in a prepartum and postpartum period with patients suffering from multiple sclerosis The theme of the bachelor thesis is an activity in a prepartum and postpartum period with patients suffering from multiple sclerosis. In the theoretical part, the multiple sclerosis itself is characterized with all its main features. The second part of the theoretics is focused on the relation between MS and pregnancy. The practical part works with the hypothesis that the health state improves during pregnancy, but unfortunatelly worsens after the birth, considering the brest-feeding. The goal of this work is to confirm this hypothesis. To conclude, the hypothesis was confirmed, except the fact that brest-feeding has a significant influence. Key words: multiple sclerosis, pregnancy, childbirth, brest-feeding, disease activity, attack, relapse, disability Generated by Foxit PDF Creator © Foxit Software http://www.foxitsoftware.com For evaluation only.
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Markers of joint inflammation related to disease activity in rheumatoid arthritis.
Hurňáková, Jana ; Pavelka, Karel (advisor) ; Horák, Pavel (referee) ; Hrnčíř, Zbyněk (referee)
Background: Rheumatoid arthritis (RA) is a common chronic autoimmune disorder characterised by persistent synovitis, typically manifested as symmetric polyarthritis of small hand joints with various extra-articular manifestations. Accurate disease activity measurement is a key component of RA management that facilitates therapeutic optimalization in order to slow down the disease progression and to prevent an irreversible joint damage. The aim of this work was to study the role of candidate serum inflammatory markers and their associations with the disease activity in patients with RA presented by traditional variables of disease activity as well as by musculoskeletal ultrasonography. Results: The first part of our work pointed out relationship between serum calprotectin and clinical as well as ultrasound activity in RA. We have revealed that serum calprotectin is an independent predictor of ultrasound synovitis. Moreover, we have demonstrated the potential of calprotectin to identify patients with residual activity in spite of achieving clinical remission. In the second part, we have provided a detailed analysis of 20 candidate serum markers and found out a tight associations between IL-6, IL-7, IL-22, IL-34, YKL-40, CXCL-13, MMP-3, resistin and visfatin with clinical and ultrasound activity....
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Activity in a prepartum and postpartum period with patient suffering from miltiple sclerosis
Řeháková, Anna ; Pavlasová, Lenka (advisor) ; Ehler, Edvard (referee)
An activity in a prepartum and postpartum period with patients suffering from multiple sclerosis The theme of the bachelor thesis is an activity in a prepartum and postpartum period with patients suffering from multiple sclerosis. In the theoretical part, the multiple sclerosis itself is characterized with all its main features. The second part of the theoretics is focused on the relation between MS and pregnancy. The practical part works with the hypothesis that the health state improves during pregnancy, but unfortunatelly worsens after the birth, considering the brest-feeding. The goal of this work is to confirm this hypothesis. To conclude, the hypothesis was confirmed, except the fact that brest-feeding has a significant influence. Key words: multiple sclerosis, pregnancy, childbirth, brest-feeding, disease activity, attack, relapse, disability Generated by Foxit PDF Creator © Foxit Software http://www.foxitsoftware.com For evaluation only.
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